“The implementation of continuous flow technology is critical towards enhancing the application of photochemical reactions for industrial process development. However, there are significant time and resource constraints associated with translating discovery scale vial-based batch reactions to continuous flow scale-up conditions. Herein we report the development of a droplet microfluidic platform, which enables high-throughput reaction discovery in flow to generate pharmaceutically relevant compound libraries. This platform allows for enhanced material efficiency, as reactions can be performed on picomole scale. Furthermore, high-throughput data collection via on-line ESI mass spectrometry facilitates the rapid analysis of individual, nanoliter-sized reaction droplets at acquisition rates of 0.3 samples/s. We envision this high-throughput screening platform to expand upon the robust capabilities and impact of photochemical reactions in drug discovery and development.”
“Development of a photochemical droplet microfluidics platform” Reproduced under a Creative Commons Attribution 4.0 International License from Sun, A.C., Steyer, D.J., Allen, A.R. et al. A droplet microfluidic platform for high-throughput photochemical reaction discovery. Nat Commun 11, 6202 (2020).
Figures and the abstract are reproduced Sun, A.C., Steyer, D.J., Allen, A.R. et al. A droplet microfluidic platform for high-throughput photochemical reaction discovery. Nat Commun 11, 6202 (2020). https://doi.org/10.1038/s41467-020-19926-z under a Creative Commons Attribution 4.0 International License.
Read the original article: A droplet microfluidic platform for high-throughput photochemical reaction discovery
Microfluidic devices are widely used to replicate the physical constraints bacteria experience in natural and…
Understanding how brain tumors interact with surrounding neural circuits is a significant challenge in neuro-oncology.…
Timely identification of infectious pathogens remains a major bottleneck in clinical care, particularly in conditions…
Early diagnosis of sickle cell disease remains a major challenge, particularly in low-resource settings where…
Understanding the interplay between surface chemistry, pore geometry, and flooding fluids remains a central challenge…
Soil hosts dense and diverse microbial communities that drive major ecological processes, yet the way…