Precise diagnosis of infectious diseases is often hindered by a lack of accessible biomarkers that can distinguish between active and past infections. While antibody levels are commonly measured, they typically fail to provide this distinction, especially in endemic contexts where antibodies can persist long...
Chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for hematologic cancers, but the process of manufacturing CAR-T cells remains a major bottleneck. Traditional protocols might stretch over 9 days and risk shifting T-cell populations toward terminally differentiated phenotypes, depleting the naive-like...
In complex tissue environments, cells constantly interact with dynamic chemical signals, many of which are transported by blood flow. Reproducing these in vitro without oversimplifying the microenvironment remains a core challenge in organ-on-chip systems. The authors of this study sought to address this by...
Lewy bodies -intracellular aggregates rich in α‑Synuclein (αSyn)- appear in a stereotyped pattern as Parkinson’s disease (PD) progresses, implying that mis‑folded αSyn travels from neuron to neuron. Animal studies and human autopsy work strongly hint that “up‑stream” axons carry the seeds backward toward their...
CD4+ T cell counts are essential for diagnosing and monitoring diseases like HIV, cancers, and even COVID-19. The current gold standard, flow cytometry, is accurate but comes with drawbacks: it’s bulky, expensive, and time-consuming, making it unsuitable for decentralized or low-resource settings. Existing microfluidic...