May 2025

Microfluidic model shows α‑Synuclein spreads backward along axons

Lewy bodies -intracellular aggregates rich in α‑Synuclein (αSyn)- appear in a stereotyped pattern as Parkinson’s disease (PD) progresses, implying that mis‑folded αSyn travels from neuron to neuron. Animal studies and human autopsy work strongly hint that “up‑stream” axons carry the seeds backward toward their...