Organ-on-a-chip systems are well established as 3D cell culture microfluidic models capable of recapitulating the in vitro microenvironment of the cells. Organ-on-a-chips can differ in various aspects such as having a monoculture/coculture, mechanical components, electrical elements for actuation or real-time readouts, etc. The combination of...
Multi-layer microfluidic chips are used for a wide variety of applications involving microfluidics. They are commonly used in organ-on-a-chip platforms where one layer encapsulates the cell culture and receives nutrients or drug formulations from the top microchannels through a porous membrane. The design and fabrication...
Iontophoresis is a transdermal drug delivery method that employs a low-intensity voltage on the skin to deliver a charged drug to the tissue often through electrophoresis or electroosmosis. This method has experienced a rise as a technique for delivering anti-cancer reagents to tumours. An accurate...
The Blood-Brain Barrier (BBB) is a highly selective membrane that separates the blood flow from the bulk of the brain and the central nervous system. This membrane is semi-permeable and ensures that the brain maintains its functionality by blocking unwanted molecules and ions from entering...
A group of researchers has now taken organ on a chips to a new level by developing a multiorgan system with circulating immune cells to mimic the immunosurveillance process. The results of this study that hinged upon a three organ microfluidic chip are reported in...