Skin diseases like atopic dermatitis and psoriasis have been linked to gut health, yet the mechanisms behind this gut–skin connection remain poorly understood. Clinical evidence suggests that an imbalance in gut microbes (dysbiosis) can disrupt the intestinal barrier, leading to skin inflammation. However, it...
In complex tissue environments, cells constantly interact with dynamic chemical signals, many of which are transported by blood flow. Reproducing these in vitro without oversimplifying the microenvironment remains a core challenge in organ-on-chip systems. The authors of this study sought to address this by...
Despite the significant advancements brought by immune checkpoint inhibitors (ICIs) in melanoma treatment, patient responses are widely varied. Researchers suspect that the gut microbiome plays a significant role in influencing these responses. The study introduces an innovative microfluidic chip model that mimics the human...
In the ever-evolving landscape of biochemical research, protein complexes characterization plays an important role in understanding the intricate mechanisms governing cellular functions. Traditional methods, while effective, often fall short when it comes to handling low-input samples or preserving the native states of protein complexes during...
Understanding of a protein’s true behavior in biological systems remains a cornerstone for understanding biological functions and addressing diseases. Traditional methods, while useful, often fall short when it comes to dealing with proteins in their natural, or native, states—particularly when these proteins are polydisperse or...