Neuromuscular junctions (NMJs) are the synaptic junctions between motor neurons (MNs) and muscle fibres and are of crucial importance in delivering signals associated with motor activities. Therefore, defects in the motor neurons or disruption in the activity of NMJs can lead to neurodegenerative diseases such...
"Low-temperature biopreservation and 3D tissue engineering present two differing routes towards eventual on-demand access to transplantable biologics, but recent advances in both fields present critical new opportunities for crossover between them. In this work, we demonstrate sub-zero centigrade preservation and revival of autonomously beating three-dimensional...
Myocardial infarction, commonly known as heart attack, causes a majority of cardiovascular disease (CVD) deaths which can be triggered by occlusion of the arteries. Finding new drugs to fight myocardial infractions requires accurate modelling of the process. In a recent article published in the lab...
Organ-on-a-chip systems are well established as 3D cell culture microfluidic models capable of recapitulating the in vitro microenvironment of the cells. Organ-on-a-chips can differ in various aspects such as having a monoculture/coculture, mechanical components, electrical elements for actuation or real-time readouts, etc. The combination of...
Multi-layer microfluidic chips are used for a wide variety of applications involving microfluidics. They are commonly used in organ-on-a-chip platforms where one layer encapsulates the cell culture and receives nutrients or drug formulations from the top microchannels through a porous membrane. The design and fabrication...