“The implementation of continuous flow technology is critical towards enhancing the application of photochemical reactions for industrial process development. However, there are significant time and resource constraints associated with translating discovery scale vial-based batch reactions to continuous flow scale-up conditions. Herein we report the development of a droplet microfluidic platform, which enables high-throughput reaction discovery in flow to generate pharmaceutically relevant compound libraries. This platform allows for enhanced material efficiency, as reactions can be performed on picomole scale. Furthermore, high-throughput data collection via on-line ESI mass spectrometry facilitates the rapid analysis of individual, nanoliter-sized reaction droplets at acquisition rates of 0.3 samples/s. We envision this high-throughput screening platform to expand upon the robust capabilities and impact of photochemical reactions in drug discovery and development.”
“Development of a photochemical droplet microfluidics platform” Reproduced under a Creative Commons Attribution 4.0 International License from Sun, A.C., Steyer, D.J., Allen, A.R. et al. A droplet microfluidic platform for high-throughput photochemical reaction discovery. Nat Commun 11, 6202 (2020).
Figures and the abstract are reproduced Sun, A.C., Steyer, D.J., Allen, A.R. et al. A droplet microfluidic platform for high-throughput photochemical reaction discovery. Nat Commun 11, 6202 (2020). https://doi.org/10.1038/s41467-020-19926-z under a Creative Commons Attribution 4.0 International License.
Read the original article: A droplet microfluidic platform for high-throughput photochemical reaction discovery
Antibiotic resistance is not always easy to detect. In some bacterial infections, most cells may…
Natural Killer cells are promising tools for cancer immunotherapy because they can recognize and kill…
Finding a trustworthy partner to partner with in your next phase of development can often…
Bacteriophages, or phages, are viruses that infect bacteria. They have shaped molecular biology for decades…
This week’s research highlight focuses on how microfluidics can help us understand the evolution of…
Understanding how the brain functions requires tools that can both stimulate and monitor neural activity…