Understanding how cells decode signals from their environment is a central challenge in biology. One such pathway, NF-κB signaling, governs immune responses and inflammation. Traditional studies usually apply static doses of cytokines, but in living tissues, signals are anything but static—they fluctuate in strength...
Circulating tumor cells (CTCs) hold the potential for cancer diagnosis and monitoring, offering a non-invasive method to track tumor evolution. However, their extreme rarity in the bloodstream and technical challenges in isolating them have severely limited their clinical utility. In a recent study published in...
Leukocyte differentiation and counting are critical for clinical diagnostics but are hindered by the low throughput and labor-intensive nature of traditional microscopy and the limitations of physical constriction microchannels in flow cytometry. A recent study in the journal of Microsystems and Nanoengineering introduces a microfluidic...
Screening for microbial proteolytic activity is essential in various biotechnological applications, including bioenergy, food processing, and pharmaceuticals. Traditional methods, such as cultivation on agar plates with skimmed milk, often result in low throughput and potential false positives from non-proteolytic activities. The need for more accurate,...
Tuberculosis (TB) remains one of the most persistent global health threats, primarily due to the ability of Mycobacterium tuberculosis (Mtb) to develop drug resistance and persist in the host for extended periods. The slow and grueling treatment process, often marred by relapse, underscores the urgent...