Metastasis, the spread of cancer cells from primary tumors to distant organs, is responsible for most cancer-related deaths. Yet, only a small fraction of circulating tumor cells survive the journey through the bloodstream and form secondary tumors. The precise mechanisms that enable this survival...
Understanding how cellular components, especially chromatin and nuclear condensates, respond to mechanical forces during confined migration is crucial. This is particularly relevant in the context of cancer metastasis, where cells must navigate through tight interstitial spaces, imposing severe mechanical deformations on the nucleus. These deformations...
In the fight against cancer, understanding the mechanics of metastasis—the process by which cancer spreads from one part of the body to another—is crucial. Cancer metastasis is a complex process that involves more than just the genetic and biochemical makeup of cancer cells; the physical...
Scientists have developed a new lab-on-a-chip device that can detect single molecules of microRNA in single cells. The device, which combines microfluidics and microarray technologies, can isolate and lyse cells and detect specific miRNA on a single chip. The method does not require nucleic acid...
In the field of cancer research, the ability to study the response of individual cells to different drugs is critical. Traditional methods of drug screening often involve large populations of cells, making it difficult to understand the variability of cellular responses. However, recent advances in...