Chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for hematologic cancers, but the process of manufacturing CAR-T cells remains a major bottleneck. Traditional protocols might stretch over 9 days and risk shifting T-cell populations toward terminally differentiated phenotypes, depleting the naive-like...
Traditional developmental toxicity (DevTox) studies largely rely on mammalian models to assess chemical impacts on development. These methods, while comprehensive, require extensive resources and time. There is a growing need for more efficient alternatives to reduce reliance on vertebrate models and enhance throughput capabilities in...
Screening for microbial proteolytic activity is essential in various biotechnological applications, including bioenergy, food processing, and pharmaceuticals. Traditional methods, such as cultivation on agar plates with skimmed milk, often result in low throughput and potential false positives from non-proteolytic activities. The need for more accurate,...
In the ever-evolving landscape of biochemical research, protein complexes characterization plays an important role in understanding the intricate mechanisms governing cellular functions. Traditional methods, while effective, often fall short when it comes to handling low-input samples or preserving the native states of protein complexes during...
Understanding of a protein’s true behavior in biological systems remains a cornerstone for understanding biological functions and addressing diseases. Traditional methods, while useful, often fall short when it comes to dealing with proteins in their natural, or native, states—particularly when these proteins are polydisperse or...