Leukapheresis is a critical treatment for children with symptomatic hyperleukocytosis, a condition where extremely high white blood cell (WBC) counts can lead to severe complications such as tumor lysis syndrome, blood clotting disorders, and organ damage. However, the conventional centrifugation-based leukapheresis technique has significant...
Despite the significant advancements brought by immune checkpoint inhibitors (ICIs) in melanoma treatment, patient responses are widely varied. Researchers suspect that the gut microbiome plays a significant role in influencing these responses. The study introduces an innovative microfluidic chip model that mimics the human...
Traditional developmental toxicity (DevTox) studies largely rely on mammalian models to assess chemical impacts on development. These methods, while comprehensive, require extensive resources and time. There is a growing need for more efficient alternatives to reduce reliance on vertebrate models and enhance throughput capabilities in...
Circulating tumor cells (CTCs) hold the potential for cancer diagnosis and monitoring, offering a non-invasive method to track tumor evolution. However, their extreme rarity in the bloodstream and technical challenges in isolating them have severely limited their clinical utility. In a recent study published in...
Leukocyte differentiation and counting are critical for clinical diagnostics but are hindered by the low throughput and labor-intensive nature of traditional microscopy and the limitations of physical constriction microchannels in flow cytometry. A recent study in the journal of Microsystems and Nanoengineering introduces a microfluidic...